Immunology

2018/06/24MEDICAL UPDATE

EHA 2018: OPTIMISMM

(Author: Maria Dalby; Interviewer: Esther Drain) Professor Paul Richardson (Boston, USA) presented the results of the OPTIMISMM study which compared the efficacy of pomalidomide, bortezomib and dexamethasone (PVd) with bortezombib and dexamethasone alone (Vd) in MM patients with 1-3 prior lines of therapy and a minimum of two cycles of lenalidomide treatment.

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2018/06/24MEDICAL UPDATE

EHA 2018: Immunotherapy in MM: why, when and how?

(Author: Maria Dalby; Interviewer: Esther Drain) The pathophysiology of MM is characterised by a state of profound immunosuppression through multiple mechanisms which provides a strong rationale for immunotherapeutic approaches including antibodies, immunomodulators, vaccines and adoptive cellular therapies. In an educational session at EHA 2018 Dr Niels van de Donk from Amsterdam outlined the importance of immunotherapy in the treatment of MM now and in the future, focussing especially the role of antibody combinations in the upfront setting and the promise of CAR-T cell therapy.

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2018/06/24MEDICAL UPDATE

EHA 2018: Preferred treatment combinations and sequencing in transplant eligible and elderly MM patients

(Author: Maria Dalby; Interviewer: Esther Drain) The growing number of novel treatments for multiple myeloma (MM) means that more patients can achieve the therapeutic goal of a deep and prolonged first remission – in some cases even to the extent that it can be described as a cure. However, optimisation of second-line therapy and beyond continues to challenge clinicians in the novel therapy era. In his presentation at a Scientific Working Group session at EHA 2018, Professor Hartmut Goldschmidt from Heidelberg in Germany reviewed strategies for treating MM patients who are eligible and ineligible for stem cell transplantation, respectively.

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2016/10/03MEDICAL UPDATE

ESH ICMM Highlights

https://vimeo.com/188277070 Professor Mohamad Mohty (Paris), Professor Sagar Lonial  (Atlanta) and Dr Karthik Ramasamy (Oxford) discuss their highlights from The European School of Haematology Congress on Multiple Myeloma this month. This issue covers the growing role of immunotherapy for managing multiple myeloma, which was the subject of one of the special lectures at this meeting, patient/physician partnerships and treatment of the transplant eligible patient.

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2016/09/05MEDICAL UPDATE

World Health Matters: Germany: Concern over hepatitis B among refugees

by Gary Finnegan: People seeking refuge and asylum in Germany are at higher risks of liver problems due to hepatitis B, according to experts.

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2016/08/18MEDICAL UPDATE

Risk of fans catching dengue fever during Olympics ‘very low’

The risk of sports fans catching dengue fever during the Rio Olympics is very low, according to a new study involving mathematicians at the University of Strathclyde.

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2016/06/24MEDICAL UPDATE

World Health Matters: Finland: Computer model estimates true impact of flu pandemic

by Gary Finnegan: Researchers in Finland have used computer modelling to estimate the true impact of infectious diseases, such as H1N1 (swine flu). Underreporting of cases means traditional surveillance systems miss the vast majority of infections that occur in the population.

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2016/02/16MEDICAL UPDATE

EMA Highlights: Europe to support Zika trials

by Gary Finnegan: The European Medicines Agency has set up a task force on Zika virus in an effort to accelerate the development of new medicines and vaccines against the disease. The group includes experts in infectious disease, vaccines and other specialists with relevant knowledge on the threat of Zika fever.

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2015/09/07MEDICAL UPDATE

World Health Matters (United States): Can ‘vaccine sceptics’ be won over?

by Gary Finnegan: The question of whether vaccines cause autism may have been settled long ago but the debate on how to share this message with the public is far from finished.

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2015/04/13MEDICAL UPDATE

Review of global guidelines for sepsis needed

Experts are calling for a global review of guidelines used to diagnose sepsis, after a study found one in eight patients with infections severe enough to need admission to an Intensive Care Unit in Australia and New Zealand, did not meet current criteria.

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